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氟诱导牙胚分泌期造釉细胞凋亡的实验研究
The effect of fluoride on the secretory ameloblast apoptosis
【摘要】 目的 探讨氟与分泌期造釉细胞凋亡的关系 ,进一步明确氟斑牙的发病机制。方法 通过建立孕鼠急性氟中毒动物模型 ,用透射电镜、缺口末端标记法 (TUNEL)观察胎鼠牙胚分泌期造釉细胞凋亡。结果 孕鼠高氟引起胎鼠牙胚分泌期造釉细胞下囊腔的形成 ,囊腔上方的造釉细胞发生了程序性细胞凋亡 (PCD)。结论 氟对造釉细胞的毒性作用是通过程序性细胞死亡的方式进行
【Abstract】 Objective To elucidate the relationship between f luoride and cell apoptosis of ameloblasts and to further study the mechanism of dental fluorosis. Methods By establishing an experimental m odel of fluoride intoxication in pregnant C57BL/6N, we observed apoptosis in the fetal secretory ameloblasts in mice by means of transmission electron microscop e and TUNEL. Results High fluoride exposure in pregnant mic e could cause subameloblastic cysts in first lower molar of fetal mice. Programm ed cell death (PCD) occurred in the disturbed ameloblasts above cysts. Conclusion Intoxicat ion mechanism of fluoride on ameloblasts may occur by means of PCD.
- 【文献出处】 西安交通大学学报(医学版) ,Journal of Xi’an Jiaotong University(Medical Sciences) , 编辑部邮箱 ,2004年01期
- 【分类号】R780.2
- 【被引频次】2
- 【下载频次】111