【摘要】 目的　探讨不同剂量膳食钙对高脂膳食大鼠血糖、血脂及激素水平的影响。方法　将雄性Wistar大鼠随机分成 6组 ,每组 9只 ,分别喂以基础饲料A组 (5 %脂肪 ,0 5 %钙 )、高脂低钙饲料B组 (15 %脂肪 ,0 0 8%钙 )、高脂正常钙饲料C组 (15 %脂肪 0 5 %钙 )、高脂高钙饲料D和E组(15 %脂肪 ,1%和 1 5 %钙 )和高脂高钙 (15 %脂肪 ,1 5 %钙 ) +维生素D(6 0 0IU % )饲料F组。 9周后断头取血测血糖、血脂和血清胰岛素、甲状腺激素、生长激素和血浆神经肽Y。结果　与C组相比 ,其它各组大鼠体重和体脂含量均显著降低 (P <0 0 5 ) ,胆固醇和甘油三酯各组与C组相比显著降低 (P <0 0 5 ) ,高密度脂蛋白各组均无显著性差异 (P >0 0 5 ) ;C组血糖和胰岛素均增高 ,与C组相比 ,E组胰岛素显著降低 (P <0 0 5 ) ,D、E、F组FT3显著增加 (P <0 0 5 ) ,E、F组神经肽Y(NPY)显著降低 ,其余各组无显著性差异 (P >0 0 5 ) ,生长激素各组间无显著性差异 (P >0 0 5 )。结论　高钙膳食可能通过降低血清胆固醇和甘油三酯 ,改善高胰岛素血症 ,降低血浆NPY ,提高血清FT3的水平 ,从而抑制了高脂膳食诱导的肥胖。更多还原

【Abstract】 Objective To explore the effects of dietary calcium on the blood glucose, blood lipid and hormone of Wistar rats fed high fat diet.Methods\ 54 male Wistar rats were randomly divided into 6 groups: A group was fed basic diet(0 5%calcium), B group was fed high fat and low calcium diet(0 08%calcium), C group was fed a high fat and normal calcium diet(0 5%calcium), D and E group was fed a high fat and high calcium diet(1% and1.5% calcium respectively), F group was fed high fat and high calcium diet (1 5% calcium)supplemented with vitamin D(600IU%). After 9 weeks, blood glucose, blood lipid and serum insulin, leptin, thyroid hormone, growth hormone, neuropeptide Y (NPY)were measured. Results\ Compared with those of C group, the body weight and body fat content decreased significantly in other groups, so did the serum cholesterol and triglyceride, but there was no significant difference among all the groups in high density lipoprotein( P >0 05). The blood glucose and serum insulin in C group increased and compared with that of C group, the insulin in E group decreased significantly ( P <0 05),the serum FT3 in D, E, F groups increased significantly ( P <0 05) and the plasma NPY in E, F groups decreased significantly. There was no significant difference among all the groups in the level of serum growth hormone( P >0 05).Conclusion Dietary reduced serum cholesterol and triglyceride, improved hyperinsulinemia, decreased plasma NPY and increased serum FT3, thereby inhibited the obesity induced by high fat diet.更多还原