【摘要】 运用pH滴定、傅立叶变换红外光谱、紫外可见光谱、激光光散射谱、ICP和元素分析等方法研究了H+的加入对水溶液中脱氧胆酸钠(NaDC)聚集体的影响.结果表明,浓度大于cmc的NaDC水溶液具有一定的缓冲能力,NaDC浓度越高,缓冲能力越大;随溶液中H+浓度的增加,首先形成质子化胶团,质子化胶团通过酸盐结构的氢键作用使NaDC初级胶团长大,形成较大的高级胶团,甚至形成凝胶体,最终形成HnNam(DC)n+m沉淀.更多还原

【Abstract】 The pH of bile is 6～8 in human gallbladder.The changes in pH will probably effect bile composition,which is important for gallstone formation.But little attention has been given to the influence of H+ on bile salts aggregates in aqueous solution.Our work focused on the changes of NaDC aggregates with adding H+ by using pH titration,FT IR,UV Vis and QELS (quasi elastic light scattering spectrometer) spectroscopies.The following conclusions are given:(1) With addition of H+ into NaDC aqueous solution above the cmc,The aggregation of NaDC micellar changs gradually into protonated micellar aggregates,secondary or mixed aggregates,and eventually gel like precipitates.(2) The strong H bond with the acid salt mode induces protonated micellar aggregation to connect with primary micelles of NaDC.(3) Therefore,aqueous micellar NaDC has a buffering capacity and can increase the solubility of HDC.更多还原