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具有免疫活性多糖海洋细菌菌株的筛选

Screening of marine bacterial strain with immunoactive exopolysaccharide

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【作者】 黄耀坚黄益丽刘三震郑忠辉宋思扬苏文金

【Author】 HUANG Yao-jian,HUANG Yi-li,LIU San-zhen, ZHENG Zhong-hui,SONG Si-yang ,SU Wen-jin (School of Life Sciences,Xiamen University, Xiamen 361005, China)

【机构】 厦门大学生命科学学院厦门大学生命科学学院 福建厦门 361005福建厦门 361005福建厦门 361005

【摘要】 从厦门海区潮间带的动植物体及底泥分离到的177株海洋细菌中筛选出一株高产胞外多糖的1202菌株.其产生的胞外多糖可显著地促进昆明种小鼠脾淋巴细胞IL 2(白介素 2)的合成,并对小鼠S180肉瘤具有较强的抑制作用.经初步分类鉴定,确定该菌株归属于土壤杆菌属(Agrobacteriumsp.).

【Abstract】 An exopolysaccharide-producing strain 1202 was obtained by screening 117 marinebacteria isolates, which were from the flora ,the fauna and the sediments in the intertidal zone of the Xiamen coast. The exopolysaccharides produced by the bacterial strain 1202 could stimulate interleukin 2 (IL-2) secretion from mouse spleen lymphocytes in vitro, and exhibit significant inhibitory effects on sarcoma 180 solid tumors in vivo. The strain 1202 was tentatively identifiedas a species of the genus Agrobacterium, based on its morphology, growth features, physiological and biochemical characteristics.

【基金】 国家自然科学基金资助项目(30070024)
  • 【文献出处】 台湾海峡 ,Journal of Oceanography In Taiwan Strait , 编辑部邮箱 ,2004年01期
  • 【分类号】Q933
  • 【被引频次】47
  • 【下载频次】372
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