【摘要】 目的 :探讨幽门螺杆菌 (Hp)感染患者血清抗幽门螺杆菌热休克蛋白60(Hsp60)抗体与消化性溃疡的关系。方法 :检测胃溃疡、十二指肠球部溃疡、慢性浅表性胃炎患者Hp感染及血清抗幽门螺杆菌Hsp60抗体表达情况。结果 :(1)血清抗幽门螺杆菌Hsp60抗体阳性表达仅见于Hp阳性患者。Hp阳性胃溃疡、十二指肠球部溃疡患者血清抗幽门螺杆菌Hsp抗体阳性率明显高于慢性浅表性胃炎患者 (均P<0.05)。(2)26例血清抗幽门螺杆菌Hsp抗体阳性的消化性溃疡患者在Hp根除及洛赛克疗程结束后4周 ,其中7例抗体转为阴性。结论 :血清抗幽门螺杆菌Hsp60抗体可能与Hp感染所致消化性溃疡的发生有关 ;血清抗幽门螺杆菌Hsp60抗体不能作为近期判断Hp根除与否的标准。更多还原

【Abstract】 Objective:To investigate the relationship between serum antibody to heat shock protein60in Helicobacter pylori(Hp)infection and the occurrence of peptic ulcer.Methods:Hp infection and serum antiˉbody to heat shock protein60of Hp was detected in patients with gastric or duodenal ulcer and chronic superˉficial gastritis.Results:(1)Serum antibody to heat shock protein60of Hp was only positively expressed in Hp infected patients.Prevalence of serum antibody to heat shock protein60of Hp was significantly higher in Hp infected peptic ulcer than that in Hp infected chronic superficial gastritis(P<0.05).(2)Seven of26cases of peptic ulcer with positive serum antibody to heat shock protein60of Hp underwent a negative serum converting of the antibody at the4th week after Hp eradication and Losec treatment.Conclusion:Serum antibody to heat shock protein60of Hp is probably associated with the occurrence of peptic ulcer in Hp infection.Serum antiˉbody to heat shock protein60of Hp can not be used to assess recent Hp eradication.更多还原