【摘要】 目的 :探讨游离前列腺特异性抗原与总前列腺特异性抗原比值和PSA密度对诊断灰区中前列腺癌的意义。方法 :用电化学发光法检测游离前列腺特异性抗原 (F -PSA)与总前列腺特异性抗原 (T -PSA)并计算比值(F/T)、PSA密度 (PSAD)。结果 :33例前列腺癌患者组与30例良性前列腺增生组T -PSA值差别无显著性意义(P>0.05)。F -PSA、PSAD差别有显著性意义(P<0.05)。F/T值差别有非常显著性意义(P<0.01)。当F/T<0.16时 ,诊断前列腺癌和良性前列腺增生的正确率分别为72 7 % (24/33)和86 7 % (26/30) ,差别无显著性意义(P>0.05) ;当PSAD<0.15ng/ml/cm3 时 ,诊断前列腺癌和良性前列腺增生的正确率分别为69 7 %(23/33)和56 7% (17/30) ,差别无显著性意义(P>0.05)。结论 :血清F/TPSA比值和PSAD对PSA灰区中前列腺癌诊断具有明显临床意义。更多还原

【Abstract】 Objective: To explore the clinical significance of detection free prostate specific antigen(F-PSA)and total prostate specific antigen(T-PSA)ratio(F/T)and prostate specific antigen density(PSAD)for diagnosis prostage cancer (PCa)with T_PSA in diagnostic gray zone.Methods:F-PSA and T-PSA was detected with electrochemiluminescent.Calculate the F/T ratio and PSAD.Results:In 33 patients with PCa and 30 patients benign prostate hyperplasia(BPH),the serum levels T-PSA were no differences(P>0.05),F-PSA and PSAD were differnet(P<0.05),F/T ratio were notable difference (P<0.01).When F/T ratio<0.16,the correct rate of diagnosis PCa and BPH were 72.7%(24/33)and 86.7%(26/30),and no differences(P>0.01).When PSAD<0.15 ng/ml/cm3,the correct rate of diagnosis PCa and BPH were 69.7%(23/33)and 56.7%(17/30),and no differences(P>0.01).Conclusion:When T-PSA in diagnostic gray zone,F/T PSA ratio and PSAD are one of significant value to diagnotice PCa.更多还原