【摘要】 为研究不对称催化合成反应,以L 亮氨酸为原料,由酯化、格式反应、还原N 烃基化反应合成3个新手性胺醇(6a,6b,6c),6b和6c经磺酰化得7a和7b.将手性配体6a,6b,6c,7a,7b分别与BH3·Me2S络合,由2种方法对芳香酮进行不对称还原,得芳香醇,不对称还原收率(ee)为3.9%～60.5%,其中手性磺胺醇的不对称催化收率较胺醇高.更多还原

【Abstract】 Asymmetric synthesis is becoming an even more interesting research area in chemistry.Aminoalcohols 6a, 6b and 6c were synthesized from L-leucine via esterification, Grignard reaction and reductive N-alkylation. Tosylation of 6b and 6c yielded 7a and 7b. After complexing with BH₃·Me₂S, 6a, 6b, 6c, 7a and 7b were tested in asymmetric reduction of aromatic ketones,to yield aromatic alcohols. The ee values ranged from （3.9%） to 60.5%. Tosylated ligands 7a and 7b gave better result than 6b and 6c.更多还原