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黄芪抗γ射线辐射对小鼠淋巴细胞增殖和IL-2的作用研究

Research of the Function of Astragalus membranaceus (AM) on the Anti-radiation of γ-Ray Lymphocyte Proliferation and Inter Leukin-2(IL-2) Production of Mice

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【作者】 郭毅曹新山李宗山邱世翠于敏

【Author】 GUO Yi 1, CAO Xin-shan 1, LI Zong-shan 1, QIU Shi-cui 2, YU Min 2 (1.Hospital of Binzhou Medical College, Binzhou, Shandong Province 256603, China; 2.Department of Immunology, Binzhou Medical College, Shandong Province 256603, China)

【机构】 滨州医学院附属医院滨州医学院免疫学教研室滨州医学院免疫学教研室 山东滨州256603山东滨州256603山东滨州256603

【摘要】 目的 :从免疫学方面探讨中药黄芪对辐射损伤小鼠淋巴细胞增殖和 IL - 2的研究。方法 :用 10 0 %黄芪水浸出液定期给小鼠灌胃 ,行γ线照射后检测小鼠淋巴细胞增殖和 IL - 2的产生。结果 :用药组小鼠脾淋巴细胞增殖和 IL - 2产生有显著增强作用 ,与照射组相比均有非常显著性差异 (P<0 .0 1)。结论 :黄芪有明显抗 γ线辐射、促进小鼠淋巴细胞增殖和IL- 2产生的作用。

【Abstract】 Objective:To research the effect of AM from the viewpoint of immunology.Methods:Filled the stomaches of the mice with 100% water extract of AM regularly, then shined with γ-radiation and tested lymphocyte proliferation and interleukin-2 production.Results:The lymphocyte proliferation and interleukin-2 production increased significantly in AM group (P<0.01) and no side effect appeared when compared with control group.Conclusion:AM could resist γ-rediation obviously and enhance lymphocyte proliferation and the production of IL-2.

【关键词】 黄芪淋巴细胞增殖IL-2小鼠
【Key words】 Astragalus membranaceus(AM)Lymphocyte proliferationIL-2Mice
  • 【文献出处】 时珍国医国药 ,LiShiZhen Medicine and Materia Medica Research , 编辑部邮箱 ,2004年09期
  • 【分类号】R285.5
  • 【被引频次】12
  • 【下载频次】161
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