【摘要】 目的 :研究丹参总丹酚酸、三七总皂苷及其不同比例配比对实验性大鼠脑缺血再灌注及多形核中型粒细胞呼吸爆发的影响 ,探讨其配伍意义及机制。方法 :通过椎动脉及颈总动脉阻断的大鼠脑缺血再灌注模型研究丹参总丹酚酸、三七总皂苷及其不同配比对脑缺血的保护作用和对血清 SOD、MDA含量的影响 ;通过化学发光法研究药物对趋化三肽激发的多形核中性粒细胞呼吸爆发的影响。结果 :丹参总丹酚酸、三七总皂苷及其不同比例配比均能减少脑缺血梗死体积 ,降低血清 MDA水平 ,抑制中性粒细胞呼吸爆发 ,且三七总皂苷及其高比例配方作用较优 ;丹参总丹酚酸不能提高血清SOD水平 ,可能通过其他途径实现抗氧化功能。结论 :丹参总丹酚酸和三七总皂苷在脑缺血保护功效上有协同作用 ,且在后者比例较高时更为显著 ;这种保护作用与增强机体抗氧化能力及抑制缺血再灌注引起的多形核中性粒细胞呼吸爆发有关。更多还原

【Abstract】 Objective:To research on the effect of total salvianolic acid(DS-SAL), panax notoginoside(PNG) and their different proportion on experimental rats cerebral ischemia re-perfusion and polymorphonuclear neutrophil(PMN) respiratory burst, discuss the significance and mechanism of its prescription.Methods:Use rats cerebral ischemia re-perfusion model established by the blockade of arteria carotis communis and arteria vertebralis, to study the protection on cerebral ischemia and the effect on serum SOD and MDA content of DS-SAL ,PNG and their different proportion.Results:DS-SAL,PNG and their different proportion may reduce the cerebral infarction volume, decrease serum MDA level and inhibit neutrophilic granulocyte respiratory burst. PNG and high PNG proportion is more significant; DS-SAL is not effective on increasing serum SOD level, it may achieve anti-oxidation through other ways.Conclusion:DS-SAL and PNG has the cooperation on cerebral ischemia protection, and is more significant on high-PNG proportion. This protection is related to the enhancement of anti-oxidation and the inhibition of cerebral ischemia re-perfusion induced PMN respiratory burst.更多还原