【摘要】 目的　探讨Kikuchi病的临床病理特点 ,为病理诊断和鉴别诊断提供依据。　方法　回顾性分析 10例Kikuchi病的临床资料 ,全部病例重新切片进行组织学观察 ,并行免疫组化染色 ,随访全部病例。　结果　 10例中女性 7例 ,男性 3例 ,年龄 14～ 42岁 ,平均年龄 2 5岁。临床主要表现为发热 ,颈淋巴结肿大和白细胞减少 ,抗生素治疗无效。组织学显示淋巴结内出现程度不同的碎片状坏死 ,伴有多种形态的组织细胞增生 ;病变区及周围有免疫母细胞和浆样单核细胞增多 ,无中性白细胞浸润。组织细胞Mac -3 87和Lysozyme(+ ) ,大多数淋巴细胞CD3和CD45RO(+ ) ;滤泡生发中心及散在的少数淋巴细胞DC2 0 (+ )。随访 4个月～ 7年 ,全部存活。　结论　Kikuchi病是一种具有特殊临床表现和独特病理特点的淋巴结炎性病变 ,预后良好。掌握其临床和病理形态学特点 ,有助于其他病变相鉴别。更多还原

【Abstract】 Obijective To study the clinical and pathological features of Kikuchi’s disease (KD) to provide more information for clinical diagnosis. Methods Ten cases of KD were collected to analyze histopathological changes and clinical date, and immunohistochemical stainings (SP method) for Mac-387, Lysozyme, CD3,CD45RO and CD20 were applied to the routine paraffin sections of all the ten cases. All the cases were followed-up. Rsults The ten cases of KD consist of 7 females and 3 males, with age ranging from 14～42 years (mean 25 years ). Main clinical feature was fever, lymphadenopathy and neutropenia. Histopathologically, lymph node show distinctive necrosis, loss of lymph node structure with many histiocytes and absence of neutrophils reaction, many plasmacytoid monocytes and immunoblasts existed. Immunophenotyping revealed CD3 and CD45RO positive for most of lymphocytes, Mac-387 and Lysozyme for histiocytes, and CD20 in follicle center cells and scattered lymphocytes. Ten patients were alive during follow-up. Conclustions KD is a morphologically distinctive disease with a comparatively favourable prognoxix. Reoognition of its clinicopathology feature is crucial to differential diagnosis of KD.更多还原