【摘要】 目的　探讨国产库型白细胞滤器在储存添加剂红细胞过滤效果。方法　使用国产血库型白细胞滤器 (BC·L 2 0 0 -1型 )过滤 15袋 10天以内的储存添加剂红细胞 (去白RBC) ,检测过滤前后WBC、RBC、PLT的浓度 ,并求出WBC、PLT的去除率 ,WBC残留量及RBC回收率 ;比较过滤前后RBC渗透脆性。并将去白RBC和非去白RBC分别用于两组患者 ,每组患者 2 0 3人 ,观察去白组与非去白组非溶血性发热性输血反应 (NHFTR)的发生率。结果　平均白细胞去除率、血小扳去除率及红细胞回收率分别为 99.3 9%、97.42 %及 93 .5 1%。开始溶血点 :过滤前后比较的t检验得P1 >0 .5 ,完全溶血点 :过滤前后比较的t检验得 0 .2 0 >P2 >0 .10。过滤前后红细胞渗透脆性无显著差异 (P1 >0 .0 5 ;P2 >0 .0 5 )。去白组NHFTR发生率为 1.48% ;非去白组NHFTR发生率为 12 .3 2 % (P <0 .0 0 5 )。结论　该型白细胞滤器的性能完全可以满足临床少白RBC输血的要求。使用该种去白RBC可以大大降低输血不良反应。更多还原

【Abstract】 Objective To get ride of the leucocytes from blood, to avoid the adverse reaction of blood transfusion. Methods 15 pockets of red blood cells were filtrated by domestic leucocyte filter (type: BCL 200-1). WBC count, RBC count, platelet count, WBC clearance rate, platelet losing rate, RBC recovery rate and osmotic fragility of RBC were detected before and after filtration. Non-hemolytic febrile transfusion reactions of filtrated RBCs and non-filtrated RBCs were observed in 203 patients respectively. Results WBC clearance rate, platelet losing rate, RBC recovery rate were 99.38%, 97.42% and 93.52%. The difference of osmotic fragility between filtrated RBCs and non-filtrated RBCs has no significant. Non-hemolytic febrile transfusion reactions of filtrated RBCs (1.48%) was lower than non-filtrated RBCs (12.32%) (P<0.005). Conclusions The quality of RBCs filtrated by domestic filter could satisfy the need of clinical using and the filtration may effectively prevent non-hemolytic febrile transfusion reactions.更多还原