【摘要】 目的　通过观察重症急性呼吸综合征 (SARS)患者康复期肺功能的变化 ,了解SARS患者是否遗留有肺功能的长期损害。方法　对 82例SARS患者出院 3个月后进行肺功能检查 (实验组 ) ,并对肺功能异常者出院6个月后再次行肺功能检查 ,并以 2 8例健康人的肺功能做为对照组进行比较分析。结果　实验组肺功能检测发现一氧化碳弥散量 (DLCO % )为 (78 4± 17 4 ) % ,对照组为 (93 8± 13 6 ) % (P <0 0 1)。出院后 3及 6个月实验组中分别有 4 6例和 30例存在弥散功能障碍 (DLCO % <80 % ) ,37例和 16例有小气道功能障碍 ,2 8例和 11例残总比增加 (RV/TLC >35 % ) ,9例和 5例有限制性通气功能障碍。按照患者住院期间胸片肺部阴影的范围 ,将患者分为轻、中、重 3组 ,其轻重程度与出院后 3个月及 6个月肺弥散功能损害呈正相关。重症患者使用机械通气治疗组与未使用机械通气治疗组肺功能损害差异不明显。结论　SARS患者治愈出院 3个月及 6个月后 ,部分患者遗留有肺功能损害 ,主要以弥散功能障碍为主 ,少数有小气道阻塞、残气增加和限制性通气功能障碍。更多还原

【Abstract】 Objective From the observation of pulmonary function changes in SARS patients during the convalescent period, we aimed to understand if there would be long-term pulmonary function lesions.Methods Pulmonary function tests were performed in 82 SARS patients 3 months after their discharge from hospital (study group) and the abnormal ones were performed pulmonary function tests 6 months after their discharge. The pulmonary function of 28 healthy persons were tesed(control group).Results Pulmonary function tests showed that the mean diffusing capacity of CO(DLCO) was (78.4±17.4)% in study group and (93.8±13.6)% in control group(P<0.01).In the study group,3 months and 6 months after their discharge from hospital,diffusing function decreased (DLCO%<80%) in 46 and 30 cases respectively,small airway function abnormality existed in 37 and 16 cases,residual volume increased (RV/TLC>35%) in 28 and 11 cases,restrictive defect in 9 and 5 cases.According to the involved areas in chest X-ray during the hospital,the study group were divided into three subgroups:mild,moderate and severe.There was a positive relation between the severity of the disease and the diffusing function lesions 3 months after discharge from hospital.There was no obvious difference in the pulmonary function lesions between the severe patients treated with mechanical ventilation and those not.Conclusion Some of SARS patients have left pulmonary function lesions 3 months and 6 months after their discharge from hospital,which mainly are diffusing capacity abnormality.A few cases have small airway obstruction,residual volume increase and restrictive defect.更多还原