【摘要】 目的　观察高尿酸血症对血管内皮功能的影响。方法　对 30例高尿酸血症男性患者和 30例正常男性采用高分辨超声技术检测血流介导和硝酸甘油介导的肱动脉舒张功能 ,并测定血浆内皮素和一氧化氮。结果　 (1)高尿酸血症患者血流介导的肱动脉舒张较正常组明显减弱 (P <0 0 1) ,而两组对硝酸甘油的血管舒张反应差异无显著性 (P >0 0 5 ) ;(2 )高尿酸血症患者血浆内皮素水平显著高于正常组 (P <0 0 1) ;一氧化氮水平显著低于正常组 (P <0 0 5 )。结论　高尿酸血症患者内皮依赖性血管舒张功能明显受损 ,血管内皮功能失调可能是高尿酸血症致动脉粥样硬化的一个重要机制。更多还原

【Abstract】 Objective To investigate the effects of hyperuricemia on vascular endothelial function.Methods With high-resolution ultrasound,flow-and nitroglycerin induced dilation,the vasodilation of brachial artery was measured in 30 hyperuricemia male patients and 30 healthy male subjects(control group).Both serum NO and plasma endothelin-1(ET-1) levels were determined at the same time.Results In patients with hyperuricemia,flow-induced vasodilation was much reduced compared with that in the control subjects(P<0.01).However,vasodilation in response to nitroglycerin was similar in both groups(P>0.05).Plasma NO level in the hyperuricemia group was lower than that in the control group (P<0.05) and ET-1 level in the hyperuricemia group was significantly higher than that in the control group (P<0.01).Conclusions Endothelium-dependent vasodilation is impaired in patients with hyperuricemia.The endothelial dysfunction may contribute to the atherogenic actions of hyperuricemia.更多还原