【摘要】 目的　从胃酸及幽门螺杆菌 (H·pylori)感染角度探讨ABO血型影响十二指肠球部溃疡 (DU)发病的因素。方法　取 1995～ 2 0 0 3年 80例DU患者入选为DU组并比较其与北京地区 10 6 1位健康对照者血型分布的差别。比较DU组不同血型发病年龄。利用快速尿素酶实验、病理学及13 C呼吸实验确定DU组不同血型者H·pylori感染率并进行比较 ;利用 2 4h胃pH监测比较DU组不同血型者一天中不同时项胃pH分布。结果　DU组O型血者占 5 6 3% ,明显高于O型血在正常人群中的分布 2 8 7% (χ2 =2 6 6 9,P <0 0 0 5 )。不同血型者DU平均发病年龄差异无显著性 (P >0 0 5 )。DU组不同血型者H·pylori感染率无统计学差别 (P >0 0 5 ) ;且一天中直立位 (主要指白天空腹时 )、卧位 (主要指夜间 )、进餐期及餐后期各时段胃内平均pH值及胃内pH值在 0～ 1,0～ 2 ,0～ 3,0～ 4……的累计时间百分比无统计学差别 (P >0 0 5 )。结论　O型血者易患DU不是通过影响H·pylori感染率或胃酸分泌来起作用的。O型血可能是DU发病的另一独立危险因素。O血型DU发病年龄不早于其他血型。其致病机制仍有待进一步研究。更多还原

【Abstract】 Objective To clarify the relationship between ABO blood group and the development of duodenal ulcer(DU)in aspects of gastric acia and Hp infection.Methods The blood group of ABO was determined in 80 patients who were diagnosed as DU and received 24-hour gastric pH monitoring between 1995 and 2003.These results were compared with the expected frequency in the 1061 healthy controls in Beijing.The prevalence Helicobacter pylori (Hp) infection rate was determined by rapid urinase test,biopsy and 13C breath test.Results Blood type O was present in 56.3% of the patients with DU,which was significantly higher than the expected rate (28.7%) in healthy population (χ 2=26.69,P<0.005).However,in DU patients,there was no difference in the average age of disease onset among different blood groups,and there was no difference of the Hp infection rates.There was no difference in the average intragastric pH level and the percentage of accumulative time at 0-1,0-2,0-3 in upright,supine position,before and after meal among different blood groups (P>0.05).Conclusion Blood group O doesn’t cause the disease by affecting Hp infection rate or stronger gastric acid secretion,it maybe another independent risk factor for DU.The onset age in blood group O is not different from that in other types.The mechanism needs to be explored.更多还原