【摘要】 目的　观察胰岛素在急性脑梗死治疗中的近期疗效 ,并讨论其机制。方法　对 1997～ 2 0 0 2年 86例非糖尿病的急性大脑中动脉梗死患者 ,随机分胰岛素组 44例和对照组 42例 ,对照组予常规治疗 ,胰岛素组在常规治疗基础上每日加用正规胰岛素 12～ 16U ,连续 7d ,观察血糖、胰岛素敏感性、欧洲脑卒中量表 (ESS)评分的变化。结果　两组间治疗前血糖、胰岛素敏感性、ESS评分均无差异。胰岛素组每日治疗后血糖均比对照组低 (P <0 0 1) ,但在正常范围内 ;14d时ESS评分胰岛素组比对照组高 (P <0 0 5)。结论　脑梗死急性期使用胰岛素使血糖维持在正常偏低水平 ,有助于神经功能的改善更多还原

【Abstract】 ObjectiveTo investigate the therapeutic effects of insulin o n acute cerebral infarction.MethodsEighty-six non-diabetes mel litus patients with acute middle cerebral artery (MCA) infarction were divided i nto two groups in random fashion:42 cases (control group) were treated by routin e methods and 44 cases (insulin group) by regular insulin on the basis of routin e methods.12～16U regular insulin per diem was administered by intravenous dripp n g in 7 days.Plasma glucose,insulin sensitivity indice (ISI) and score values of the European Stroke Scale (ESS) were observed.ResultsThere wer e no statistically significant differences between the 2 groups at baseline.The everyday plasma glucose levels of the insulin group.were within the normal range but were significantly lower than those of the control group (P<0 01).The score values of ESS were significantly higher at the 14th day (P<0 05) in t he insulin group.ConclusionsInsulin can help repair injured ne rves by controlling plasma glucose at lower but normal levels in acute cerebral infarction.更多还原