【摘要】 目的 :探讨Sj gren综合征 (Sj gren’ssyndrome ,SS)与性激素的关系 ,以期为临床开展内分泌治疗提供理论依据。方法 :采用免疫组织化学法 ,检测 2 8例SS涎腺组织和 19例正常涎腺组织中雌激素受体 (ER)、雄激素受体 (AR)的表达情况。结果 :正常组与SS组ER的阳性率分别为 5 7.89%和 75 .0 0 % ,无显著性差异(P >0 .0 5 ) ;AR的阳性率分别为 84.2 1%和 5 0 .0 0 % ,有显著性差异 (P <0 .0 5 ) ;ER和AR主要位于腺泡和导管上皮细胞胞核内 ,而淋巴细胞仅偶见染色 ;SS唇腺、腮腺、颌下腺、舌下腺组织中 ,二者都为弱阳性到阳性染色 ,表达情况未见明显差异 (P >0 .0 5 )。结论 :SS涎腺病变与局部雄激素作用降低或丧失有关 ,雌、雄激素通过相应受体直接作用于涎腺上皮细胞 ,影响SS涎腺病变的发生与发展更多还原

【Abstract】 Objective: To investigate the expression of estrogen receptor(ER) and androgen receptor(AR) in salivary gland tissues in patients with Sjgren’s syndrome(SS). Methods:ER and AR in salivary tissues from 28 SS patients and 19 normal controls were detected by immunohistochemical staining . Results: Positive rate of ER in normal and SS salivary tissues was 57.89% and 75.00% (P>0.05),that of AR 84.21% and 50.00% (P<0.05),respectively.ER and AR were found within nuclei of acinar and ductal epithelial cells in SS salivary tissues, while lymphocytes were stained occasionally. Staining density of ER and AR were faint or moderate in SS, and there were no significant differences in different salivary glands(parotid, submandibular, sublingual and labial glands)(P>0.05). Conclusions: The pathogenesis of SS salivary glands appears to be linked to decrease or loss of topical action of androgens.Sex hormones act on epithelial cells of salivary glands through corresponding receptors.更多还原