【摘要】 目的 :探讨涎腺腺样囊性癌层粘连蛋白 (LN)与血管内皮生长因子 (VEGF)表达的意义。方法 :采用免疫组织化学SP法检测 3 4例涎腺腺样囊性癌LN和VEGF的表达。结果 :LN表达与病理分型、淋巴结转移有关 ,与临床分期、发病部位、肿瘤大小无关 ;VEGF表达与病理分型、淋巴结转移、临床分期有关 ,与发病部位、肿瘤大小无关。结论 :LN和VEGF的表达可作为判断涎腺腺样囊性癌生物学行为的指标。更多还原

【Abstract】 Objective:To evaluate the significance of expression of laminin (LN) and vascular endothelial growth factor(VEGF) in adenoid cystic carcinoma of salivary glands. Methods:Ultrasensitive immunohistochemical staining(S-P) was used to examine LN and VEGF expression in specimens from 34 patients with adenoid cystic carcinoma of salivary glands.Results:Higher LN expression was found in adenoid or tubular type of the cases (P<0.05)and in the cases with lymph node metastasis(P<0.05). LN expression was not related to the clinical stage, site and size of the tumor(P>0.05). Higher VEGF expression was found in stage Ⅲ-Ⅳ of the tumor (P<0.05) and in the cases with lymph node metastasis (P<0.05). VEGF expression was not related to the site and size of the tumor (P>0.05). Conclusion: LN and VEGF expression may be served as one of the predictors for the biological behavior of adenoid cystic carcinoma of salivary glands.更多还原