【摘要】 目的 :在建立模拟临床双侧上颌前部裂及上颌前颌骨加压的定量研究实验动物模的基础上 ,探索受压骨缝组织的微观结构变化的规律。方法 :12只 3周龄雌性新西兰大耳白兔 ,随机均分为 3组 :空白对照组 ;实验Ⅰ组 ,前颌后推加较小力 ;实验Ⅱ组 ,前颌后推加较大力。分别在术后 3、6、9、12周处死动物 ,取受压迫的前颌上颌骨缝标本 ,切片用于光镜和电镜观察。结果 :在骨缝生长发育的过程中 ,骨缝受一定程度压力后其成骨层的成骨细胞出现损伤 ,并与受力大小成正比。结论 :发育早期骨缝受压会导致该部成骨细胞出现延滞性损伤 ,在一定范围内骨缝基本结构及生长潜力不易被广泛破坏更多还原

【Abstract】 Objective: To study the microcosmic and pathological changes of compressed premaxillary suture in rabbit models with the cleft in premaxilla.Method: 12 male New Zealand rabbits, at the age of 3 weeks were designed randomly into 3 groups with 4 in each. In group 1and 2 a retropress force of 2.24 and 1.12 N was applied on the maxilla of the animals respectively. The other group was the control. The experimental animals were killed and compressed premaxilla suture specimens were examined by microscopy and electron microscopy 3,6,9 and 12 weeks after operation respectively. Result:In group 1 disturbance of microstructure and degeneration of osteoblasts were observed 3 and 6 weeks after application of the compress force. In control group normal bone structure and development of maxilla were observed. The microcosmic changes in group 2 were similar to those in group 1, but slighter. The microcostructure in the compressed premaxilla tended to be normal 9 weeks after operation. Conclusion:Compress force on premaxillary suture may result in limited pathological changes of the bone during early developing stage.更多还原