【摘要】 目的 :探讨灯盏花注射液对大鼠脑缺血再灌注损伤的保护作用及其机制。方法 :采用大鼠双侧颈总动脉闭塞的不完全性脑缺血再灌注模型 ,并于结扎前 30 min给灯盏花组腹腔注射灯盏花注射液 ,分别测定血浆中一氧化氮 ( NO)及中分子物质 ( MMS)总量和脑组织中丙二醛 ( MDA)含量变化。结果 :灯盏花显著增加缺血大鼠血浆中 NO含量 ,降低MMS总量和组织中 MDA的含量 ,以及降低血比粘度。结论 :灯盏花注射液对大鼠脑缺血再灌注损伤具有保护作用 ,其机制与抗脂质过氧化、增加 NO含量和降低 MMS总量作用有关。更多还原

【Abstract】 Objective:To observe the protective effects of breviscapini on acute brain ischemia reperfusion injury in rats. Methods:The content of plasma nitric oxide (NO) and middle molecule substance(MMS) and the content of brain tissue malondialdehyde(MDA) were detected using the models of incomplete brain ischemia reperfuion in rates by closing bilateral common carotid arteries. Results:Breviscapini significantly increased nitric oxide content and reduced middle molecule substance and malondialdehyde content and viscosity of blood injury in rats.Conclusion: The protective effects of breviscapini on cerebral ischemia injury may be related to its antilipid peroxidation,its increasing NO and decreasing MMS.更多还原