【摘要】 关节软骨是覆盖关节表面的一层承载生物重量的组织。关节软骨在正常状态下,软骨蛋白多糖的弹性和胶 原纤维的张力保持平衡。这种平衡的微小变化会引起关节软骨的退化。关节软骨特别是其表层区域的膨胀是和 骨关节炎的退化相联系的,定量的测量关节软骨的膨胀可以表征骨关节炎的退化变化。本文的主要目的是介绍一 种新的实时超声膨胀测量系统,并把该系统应用到关节软骨的研究中。该系统使用50MHz的超声来实时动态观 测用胰岛素和0.15M生理盐水溶液分别浸泡处理的牛膝盖关节软骨的非均匀瞬时深度依赖膨胀行为。实验表 明,实时超声检测的方法为关节软骨的退化研究提供了独特的工具。这项技术结合关节内窥镜检查,具有潜在的 早期诊断体内关节退化的价值。更多还原

【Abstract】 Articular cartilage (AC) is a biological weight-bearing tissue covering the bone ends of articulating joints. Under normal conditions the proteoglycan elasticity keeps balance with the collagen tension in articular cartilage. Subtle changes of this balance may lead to the degeneration of AC. Quantification of these swelling effects in AC, particularly in superficial zones, can be used to characterize degenerative changes associated with osteoarthritis. This paper introduces a new real-time ultrasound swelling measurement system used for investigation of AC. The system with 50MHz ultrasound was used to monitor in real-time the inhomogeneous transient and depth-dependent swelling behavior of bovine patellar AC which was bathed by trypsin and 0.15M saline solution respectively. The experimental results show that the method of real-time ultrasound measurement provided a particular tool to study the degeneration of articular cartilage. This technique can be potentially used for early diagnosis of cartilage degeneration in vivo through an arthroscope.更多还原