【摘要】 合成了5,7-二甲基-1,2,4-三唑并[1,5-a]嘧啶-2-苄硫醚类(A系列)和5,7-二甲基-1,2,4-三唑并[4,3-a]嘧啶-3-苄硫醚类(B系列)化合物,并通过熔点测定、红外光谱、核磁共振氢谱对其结构进行了表征.与以前不同的是,在合成过程中,我们改变反应温度,并使用相转移催化剂苄基三甲基溴化胺,在氢氧化钠的乙醚-水溶液中进行了相转移反应,该合成方法反应条件温和,所得产物更纯、产率更高.更多还原

【Abstract】 A series of new 2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines and 3-(Alkythio)-1,2,4-triazolo[4,3-a]pyrimidines were synthesized.All compounds were characterized by IR,()~1H NMR spectra.Instead of original alkylation procedure, we used phase transfer reaction in ether-aqueous sodium hydroxide with benzyltrimethylammonium bromide at room temperature, and thereby purer products and higher yield were obtained.更多还原