【摘要】 目的研究人结缔组织生长因子的透皮吸收。方法应用氯胺T法制备125I-人结缔组织生长因子(125I-rCTGF),采用家兔进行不同剂量的125II-rCTGF的完整皮肤和破损(烫伤)皮肤吸收试验。结果125I-rCTGF的比活度为2.0×105计数/(分.μg)。皮肤吸收试验表明,不同剂量125I-rCTGF透皮给药后家兔均未能通过皮肤经毛细血管吸收入血。结论为重组人CTGF临床试验提供必要的实验数据。更多还原

【Abstract】 Objective To study the percutaneous absorption of human connective tissue growth factor (CTGF) . Methods Prepare 12S I-labeled human CTGF by chlormaine T method. Test the percutaneous absorption of the CTGF at various dosages on intact and scalded skins of rabbits. Results The specific activity of125I - labeled rCTGF was 2.0× 105counts/ (min·μg) . No 125I-labeled rCTGF administered percutaneously was absorbed into blood. Conclusion The study provided experimental evidence for the clinical trial of rCTGF.更多还原