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Cox回归模型在肝癌病人生存分析中应用的研究

The Application of COX Regression Model in the Survival Analysis of liver Cancer

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【作者】 曾照芳安琳王济明

【Author】 ZENG Zhao-fang AN Lin WANG Ji-ming(Chongqing University of Medical Sciences, Chongqing 400016 China)(The Outpatient Department oj Chongqing Military Representative Bureau ofPLA General Armament Department, Chongqing 400042 China)(Department oj Surgery, College of Clinical Medicine,Chongqing Medical University, Chongqing 400042 China)

【机构】 重庆医科大学总装重庆军代局门诊部重庆医科大学临床学院普外科 重庆 400016重庆 400042重庆 400016

【摘要】 生存时间是癌症患者和临床医师共同关心的焦点,也是临床癌症诊治工作的重要指标之一。生存分析是研究多种因素与生存时间的关系以及关系程度的大小,Cox回归模型是生存分析中常用的方法之一。本文利用Cox回归模型对786名肝癌患者进行生存分析,确定影响肝癌患者预后的主要因素是癌栓、肝癌部位、治疗方式、肝脏储备功能、端粒酶活性、细胞增殖活性、γ-GT(γ-谷氮酰转肽酶)、术后复发等.为临床研究延长肝癌病人的生存期,提高其生存率提供了有力的依据。

【Abstract】 Survival period is a critical point that both patients of cancer and physicians most concern, and is an important parameter to clinical diagnosis and treatment of cancer.. Survival analysis studies the various factors effecting the survival period and the degree of its relationship COX regression model is one of the most common methods in the survival analysis. In this paper the survival period of 786 cases of liver cancer are analyzed using COX regression model . It is concluded that the main factors influencing the prognosis of treatment of liver cancer are the thrombosis of carcinoma ,location of liver cancer , method of treatment , backlog function of liver,activity of telomerase,activity of cell proliferation ,r-GT and the recur afterwards the operation . Data and its analysis is a useful reference to the clinical research to prolong survival period and increasing the survival rate of liver cancer patients.

【关键词】 Cox回归模型肝癌生存分析
【Key words】 COX regression modelLiver CancerSurvival analysis
  • 【文献出处】 生物数学学报 ,Journal of Biomathematics , 编辑部邮箱 ,2004年01期
  • 【分类号】R735.7
  • 【被引频次】10
  • 【下载频次】1106
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