节点文献
蛋白质交联的研究进展
Proceeding in Protein Cross-linking
【摘要】 蛋白质共价交联不但存在于一些生理过程 ,还与一些神经性疾病的发病机理相关。本文综述国内外 3种观点 ,阐述蛋白质由功能体 /单体转变成交联的二聚体 /多聚体的分子机理
【Abstract】 Protein cross-linking is involved in several biological processes, and is common in a group of diseases characterized by abnormal protein deposition. This article summarized three hypothetic theories from home or overseas to expatiate the molecular mechanism for converting monomeric/functional forms of proteins into cross-linked dimeric/oligomeric forms.
【关键词】 蛋白质交联;
异肽键;
二硫键;
朊蛋白性脑病;
谷氨酰胺转移酶;
【Key words】 Protein cross-linking Isopeptide bond Prion disease Disulfide bond Transglutaminase;
【Key words】 Protein cross-linking Isopeptide bond Prion disease Disulfide bond Transglutaminase;
【基金】 国家自然科学基金项目 (NO .3 980 0 0 2 8);北京市科技新星计划项目 (NO .9612 8)
- 【文献出处】 生物技术通报 ,Biotechnology Information , 编辑部邮箱 ,2004年04期
- 【分类号】Q51
- 【被引频次】8
- 【下载频次】780