【摘要】 目的 :通过改变冷冻干燥的工艺条件 ,缩短制备聚合物多孔支架的时间。方法 :把冷冻好的聚合物溶液在溶剂的冰点以上直接真空升华干燥 ,通过对支架的孔结构和外观的考察 ,评价其作为制备多孔支架工艺的可行性。结果 :制备了壳聚糖、胶原、明胶 3种不同材料的支架 ,都具有均匀的通孔结构 ,可应用于组织工程研究。结论 :在比冰点高的温度下对冷冻的样品进行真空干燥 ,可以制得多孔支架 ,并能使制备的时间大大缩短 ,但该工艺方案有时会产生开裂和塌陷 ,影响支架的质量 ,因此还有待进一步完善。更多还原

【Abstract】 Objective It is to reduce the time of preparation of natural polymer porous scaffolds by adjusting the processing condition of freeze-drying. Methods The freezed polymer solution was sublimated in a vacuum container above the freezing point temperature of the solvent and the feasibility of this process was evaluated by investigating the pore structure and appearance of polymer porous scaffolds.Results The porous scaffolds of chitosan, collagen and gelatin were fabricated. The scaffolds possess a uniformly interconnected pore structure and can be used for the research of tissue engineering.Conclusion The natural polymer porous scaffolds can be prepared by vacuum drying at the temperature above freezing point of the solvent, and the processing time of scaffolds can be reduced obviously. It can be consumed much less energy than former freezing-drying process. The porous scaffolds fabricated by this method could crack and collapse sometimes, so the process still requires improving further.;更多还原