【摘要】 目的 :评价同期化、放疗对局部晚期鼻咽癌 (NPC)的效果。方法 :回顾性分析病理确诊为Ⅲ、Ⅳa期的初诊NPC 38例行同期化、放疗 (化放组 )的临床资料 ,并与同期行单纯放疗 (单放组 ) 38例进行比较。结果 :两组 3年总生存率 (OS)、无瘤生存率 (DFS)、无复发生存率和无远处转移生存率均无统计学意义 (P >0 0 5 ) ,但对于T3 4N0 1M0期患者 ,化放组 3年OS和DFS明显高于单放组 (93%、 5 2 %,86 %、 33%,P <0 0 5 )。结论 :本研究未能证实同期化、放疗对提高Ⅲ、Ⅳa期NPC患者的生存率有好处 ,但分层研究提示有利于提高T晚期 (T3 4N0 1M0 )NPC患者的DFS和OS。更多还原

【Abstract】 Objective:To evaluate the effect of concurrent chemoradiotherapy on locoregionally advanced nasopharyngeal carcinoma(NPC).Methods:The retrospective clinical data of 38 patients who were newly diagnosed and pathologically proven as NPC with Stage Ⅲ and Ⅳa and treated by concurrent chemoradiotherapy,were analyzed and matched with those of 38 patients who were simultaneously treated by radiotherapy.Results:No difference was noticed in the 3-year overall survival(OS),disease-free survival(DFS),relapse-free survival and distant metastasis-free survival rates between two groups(P>0.05).For the patients with Stage T3-4N0-1M0,the 3-year OS and DFS in chemoradiotherapy group were higher than those of the radiotherapy group(93%,52% for OS and 86%,33% for DFS,P<0.05).Conclusion:Our study fails to confirm any improvement on survival in patients with Stage Ⅲ and Ⅳa NPC treated by concurrent chemoradiotherapy.Nevertheless,the stratified analyses indicate that the concurrent chemoradiotherapy be-nefits DFS and OS of the patients with advanced T Stage(T3-4N0-1M0).更多还原