【摘要】 本文以蔗糖为原料,经三苯基氯甲烷和乙酸酶保护羟基,然后用乙酸脱去三苯甲基和完成乙酚基迁移,再与氯化亚矾进行氯代反应,最后在甲醇-甲醇钠体系中脱去乙酸基而制得三氯蔗糖。产品收率为14.7%,纯度为99.5%。更多还原

【Abstract】 This article studied the conversion fo sucrose through four setp synthesized into sucralose (1) blocking alcohlo groupswith trityl chloride and acetic anhydride; (2)detritylating and migrating acetyl group with acetic acid; (3)chlorinating withthionyl chloride and (4)deacetylating with methanol-sodium methoxide. The yield was 14.7% and the purity 99.5%.更多还原