【摘要】 ①目的　观察毛细支气管炎病儿血清免疫球蛋白E(IgE)、白细胞介素 4 (IL 4 )、肿瘤坏死因子 (TNF)的变化 ,探讨其与哮喘的关系。②方法　毛细支气管炎病儿 6 2例 ,分别于急性期、缓解期和半年后随访时取静脉血 ,采用酶联免疫吸附分析法 (ELISA)测定血清IgE、IL 4和TNF的变化 ,并与健康儿童 31例进行对比。③结果　毛细支气管炎急性期病儿IgE、IL 4和TNF不仅明显高于对照组 (F =4 .98～ 7.2 1,q =3.76～ 5 .92 ,P <0 .0 1) ,而且也高于缓解期病儿 (q=2 .83～ 4 .5 8,P <0 .0 5、0 .0 1) ,缓解期IgE、IL 4仍明显高于正常对照组 (q =2 .80、2 .87,P <0 .0 5 )。随诊时发生哮喘和毛细支气管炎反复发作的病儿上述三项指标仍明显增高 ,与正常对照组比较有显著差异 (F =4 .78～ 7.92 ,q =2 .80～ 4 .38,P <0 .0 5、0 .0 1) ,而无反复发作的病儿各项指标与对照组比较无显著性差异 (q =2 .0 3～2 .5 1,P >0 .0 5 )。④结论　IgE、IL 4和TNF与儿童毛细支气管炎发病密切相关 ,可作为预测高危哮喘转化为哮喘的客观实验室指标更多还原

【Abstract】 Objective To observe the changes of immunoglobulin E(IgE), interleukin-4(IL-4) and tumor necrosis factor(TNF) in patients with bronchiolitis and to study the relationship between them and the incidence of asthma. Methods The serum IgE, IL-4 and TNF were measured in 62 patients and 31 controls by enzyme-linked immunosorbent assay(ELISA). Results The serum IgE, IL-4 and TNF in the acute patients increased significantly compared with those in the controls(F=4.98-7.21, q=3.76-5.92,P<0.01) and mild patients (q=2.83-4.58, P<0.05,0.01). Compared with those of the controls, the serum IgE and IL-4 also increased greatly (q=2.80,2.87,P<0.05), the serum IgE, IL-4 and TNF increased markedly in patients who had developed asthma or were attacked repeatedly (F=4.78-7.92, q=2.80-4.38, P<0.05, 0.01), but not significantly in patients without paroxysmal episodes (q= 2.03- 2.51, P> 0.05). Conclusion IgE, IL-4 and TNF are closely related to the incidence of bronchiolitis in children and can serve as objective laboratorial indexes to predict high-risk asthma turning into asthma.更多还原