【摘要】 目的　总结 10年来应用伽玛刀 (γ 刀 )治疗颅内病变 5 5 0 8例的经验体会。方法　对 5 5 0 8例中常见的垂体瘤 1387例治疗 ,统计 15 8例巨大垂体瘤治疗效果与方法 ;听神经瘤 312例中 5 0例复发治疗随访结果 ;脑膜瘤 4 6 0例中进行随访 ;脑动静脉畸形 5 2 7例中统计 130例随访结果 ;74 0例脑转移瘤治疗中 5 5 6例随访结果进行总结。结果　垂体瘤γ 刀的治疗总有效率为 98.1% ,听神经瘤有效率为 4 1.6 % ,脑动静脉畸形有效率为 83.3% ,脑转移瘤有效率为 81.8%。结论　γ 刀已成为神经外科领域重要的治疗手段之一 ,但应进一步根据有关生物学试验及临床病人个体反应来阐明脑组织及脑血管对不同放射剂量的反应以提高疗效 ,使之更成功地应用到临床更多还原

【Abstract】 Objective To summarize the experience of 5 508 patients with intracranial lesion after Gamma knife treatment.Methods 1 387 patients with pituitary adenoma were treated by Gamma knife, and therapeutic efficacy and methods of 158 patients with giant pituitary adenoma were statistically analysed. Among the 312 patients with acoustic neuroma treated by Gamma knife, 50 patients were recurrent after operation, whose results of follow-up were investigated; the results of follow-up in 460 patients with meningioma were investigated; among 527 patients with arterio-venous malformations, the follow-up results of 130 cases were investigated.Results After treatment the rates of effective therapy of pituitary adenoma, acoustic neuroma, arterio-venous malformation and cerebral metastatic tumor were 98.1%, 41.6%, 83.3% and 81.8% respectively.Conclusion Gamma knife has become one of the most effective therapeutic tools in the neurosurgical field. To improve the therapeutic efficacy, more studies should be conducted on the relevant biological mechanism and individual reaction to explain the reaction of brain tissues and cerebral vessels for different radiation dosage.更多还原