【摘要】 为探讨克癌临 (主药 :半枝莲、仙鹤草等 )抑制癌症发生的作用机制 ,以DEN诱生大鼠肝癌 ,观察诱癌 8周和 16周时大鼠肝脏组织形态及p5 3、bcl- 2基因表达等的改变。结果 :克癌临组大鼠的肝脏增长性病变在 8周和 16周时均明显轻于模型组 ;p5 3和bcl- 2表达少于模型组 ,比较其积分光密度值均有显著差异 (P <0 0 5或P <0 0 1)。提示下调p5 3和bcl - 2基因表达 ,可能是该药抑制DEN诱发大鼠肝癌的机制之一更多还原

【Abstract】 To explore the mechanism of “Ke Ai Lin” in preventing liver carcinoma that is induced by DEN in rats, the liver morphology and p53 and bcl-2 expressions were detected at the 8week and 16week. Results: At the 8-week and 16-week time, the proliferation of liver tissues was milder in treatment group than in model group; p53 and bcl-2 expressions were lower in treatment group than in control group; and there was a significant difference in the optic density between the two groups (P<0.05-0.01). It is indicated that “Ke Ai Lin” can lower the p53 and bcl-2 expressions eventually to inhibit liver caecinoma.更多还原