【摘要】 探讨中药参阳方 (主药 :党参、黄芪、丹参、锁阳、女贞子等 )的急性与慢性毒性反应。进行常规的小鼠经口急性毒性试验 ,并通过建立移植瘤模型 ,观察该方对荷瘤裸鼠的长期慢性毒性反应和对其生存期的影响。结果 :参阳方经小鼠灌胃的日最大耐受量为 5 0 g/kg体重 ,相当于临床用药量的 10 7倍 ;对荷瘤裸鼠的生存期无影响 ;心、肝、肾标本光镜下均未见病理学改变。提示参阳方对小鼠、荷瘤裸鼠无明显的急性及慢性毒副反应更多还原

【Abstract】 The acute and chronic toxic effects of "Shenyang Decoction" were evaluated. The routine acute toxic test on mice was performed by perfusing the mice with "Shenyang Decoction"; the chronic toxic responses of nude mice with tumor to "Shenyang Decoction" and its influence on survival stage were observed through setting up tumor-bearing model. Results: The maximum tolerance dosage of mice to "Shenyang Decoction" through mouth was 50g/Kg BW, which was 107 times as clinical dosage; there was no effects of "Shenyang Decoction" on the survival stage of nude mice with tumor; no microscopic changes were found in the heart, liver and kidney. It is proved that "Shenyang Decoction" has no acute and chronic toxicity.更多还原