【摘要】 目的　分析颈总动脉内膜 中层厚度 (IMT)增厚的危险因素。方法　心内科的住院病人 14 2例 ,分别以高频超声检测其IMT ,并以IMT≤ 1.0mm或 >1.0mm分成正常IMT和IMT增厚两组。血液生化指标检查包括 :三酰甘油 (TG)、总胆固醇 (TC)、高密度脂蛋白 (HDL)、低密度脂蛋白 (LDL)、空腹血糖 (FBG)、尿酸 (UA)、肌酐 (Cr)、尿素氮 (BUN)等 ;所有病人均做CPn IgG检测。分别以单因素和多因素分析对以上因素及糖尿病、血脂代谢紊乱、高血压、吸烟、年龄与IMT的关系。结果　以IMT增厚与否进行分组 ,两组间年龄 [(5 2 .3± 10 .5 )对 (6 4 .1± 7.7)岁 ;t=7.5 6 8,P <0 .0 0 1]、收缩压 [(18.17± 3.0 3)对 (19.4 4± 3.0 0 )kPa ;t =2 .4 12 ,P =0 .0 17]、BUN[(5 .5 6± 1.74 )对 (6 .2 8± 1.6 5 )mmol/L ;t=2 .394 ,P =0 .0 18]、UA[(32 1.2± 82 .7)对 (35 6 .3± 86 .7)mmol/L ;t=2 .386 ,P =0 .0 18]、LDL[(2 .5 4 3± 0 .80 6 )对 (2 .96 7± 1.16 3)mmol/L ;t=2 .2 96 ,P =0 .0 2 4 ]有差异 ;两组间CPn IgG阳性率略有差别 ,但差异无统计学意义 (4 6 .1%对 6 0 .4 % ;χ2 =2 .72 3,P =0 .0 99) ;其余包括吸烟史、舒张压及各项生化指标两组间差异均无统计学意义。多因素逐步回归分析发现 ,年龄和LDL是IMT增厚的更多还原

【Abstract】 Purpose To investigate the risk factors of common carotid intima-media thickness (IMT). Methods One hundred and forty-two patients were collected from the ward of cardiology.IMT of common carotid were measured by two investigators with 7.0 MHz liner array B-mode transducer.All patients were divided into group 1 and goup 2 by IMT,which is≤1.0 mm or>1.0 mm.The factors including smoking,abnormal lipid,hypertension,diabetes mellitus,ages,triglycerides (TG),total cholesterol (TC),high dense lipoprotein (HDL),low dense lipoprotein (LDL),blood urea nitrogen (BUN),creatinine (Cr),uric acid (UA),fast blood glucose (FBG) and IgG of chlamydia pneumoniae (CPn) were analyzed for the relationship with IMT.Using multiple logistic regression analysis. Results The results of comparing between group 1 and group 2 were ages [(52.3±10.5) vs (64.1±7.7) yrs;t=7.568,P< 0.001],SBP [(18.17±3.03) vs (19.44±3.00)kPa;t=2.412,P=0.017],BUN [(5.56±1.74) vs ( 6.28±1.65) mmol/L;t=2.394,P=0.018],UA [(321.2±82.7) vs (356.3±86.7) mmol/L;t= 2.386,P= 0.018],LDL[(2.543±0.806) vs (2.967±1.163) mmol/L;t=2.296,P=0.024].The result of logistic regression analysis (Forward:LR):OR of ages was 1.137 (95%CI∶1.079-1.188),LDL was 1.618 (95%CI∶1.054-2.482) by adjustment for other risk factors. Conclusions Age and LDL are the main factors of increased IMT.Other correlative factors include UA,BUN.The infection of CPn in positive related with IMT,but may not be a main factor.更多还原