【摘要】 组织酸化可以导致痛觉的产生 .初级感觉神经元可以通过离子通道来感受外周的组织酸化 .已鉴定了几个离子通道家族可能参与了外周组织酸化的感受 :a 酸敏感离子通道 (ASICs)是可以被酸直接门控的阳离子通道 ;b 辣椒素受体 (VR1)可被酸敏化 ,同时可被pH <6 0直接激活 ;c P2X2和P2X2 / 3受体通道反应被酸上调 ;d TwIK相关的酸感受钾通道 (TASK)是被酸关闭的双孔内向整流钾通道 .这些通道被酸所调控的共同结果就是提高了神经元的兴奋性 .因此 ,它们在介导了组织酸化所诱导的痛觉感受和传递中具有重要作用更多还原

【Abstract】 Tissue acidosis can directly induce pain sensation which is mediated by ion channels in peripheral sensory neurons. To date, several ion channel superfamilies are identified to be involved in the pain from tissue acidosis. (1) ASICs can be gated by proton and directly mediate the acidosis pain; (2) VR1 can be sensitized by acidosis as well as activated by pH<6 0; (3) P2X2 receptor is up-modulated whereas P2X3 is down-modulated by acidosis; (4) TASK is one of the tandem pore and the inwardly rectifying K+ channel which can be closed by acidosis.更多还原