【摘要】 基因表达受不同层次的调控 .RNA干扰通过产生双链小RNA诱导同源mRNA序列降解 ,从而在转录后抑制特定基因的表达 .最新的研究成果显示 :RNA干扰产生的双链小RNA可通过与染色质中的重复序列DNA及组蛋白甲基化酶相互作用 ,引起组蛋白H3Lys9的甲基化 ,进一步与异染色质形成相关蛋白结合 ,导致染色质沉默 .综述了RNA干扰 ,小RNA ,组蛋白修饰 ,染色质沉默及基因表达调控之间存在着精密的网络调控机制 .更多还原

【Abstract】 Gene expression is regulated at different levels. RNA interference is the mechanism through which double-stranded short RNAs silence cognate genes. Recent research work demonstrates that double short RNAs can not only repress the gene expression at post-transcriptional level, but also have a close relationship with chromatin silencing by directed H3 Lys9 methylation, DNA methylation and combining with other heterochromatin proteins. The mechanism existed in RNA interference, short RNAs, chromatin modification and chromatin silencing has been disclosed.更多还原