【摘要】 Notch是一个进化上十分保守的跨膜受体蛋白家族 ,它可以通过与表达配体的相邻细胞间的相互作用转导信号 ,从而决定动物系统发育过程中多种细胞的“命运” .Notch信号转导过程包括Notch受体与配体的结合、Notch受体的酶切活化、可溶性NICD转移至细胞核并与CSLDNA结合蛋白相互作用 ,从而调控靶基因的表达 .Notch活性水平、时间和空间分布受到包括配体、蛋白质转运、泛素化降解等多水平内源性和外源性诱导因素的调节 .系统介绍了Notch信号转导通路的分子组成、Notch信号激活的生化机制、Notch信号的多水平调节以及与部分相关疾病的关系 .更多还原

【Abstract】 Notch is an evolutionarily conserved single-span transmembrane protein family that is used to regulate cell fate determinations during metazoan development. Notch signalling is mediated by a well-established mechanism that relies on a transmembrane ligand-induced release of the Notch intracellular domain (NICD) and the interaction of this fragment with the CSL (CBF1, Suppressor of Hairless, Lag-1) family of transcription factors within the nucleus. Level, duration and spatial distribution of Notch activity can be regulated through combination with intrinsic or extrinsic inducing factors at multiple levels including Notch-ligand interactions, trafficking and ubiquitination of Notch and ligands. The molecular components that participate in Notch signalling, central events of Notch signalling, multiple levels of Notch signal regulation and the relation with some human diseases are reviewed.更多还原