【摘要】 目的比较采用Szenohradszkay模型罗库溴铵药代学参数进行TCI与间断单次静注法的肌松效应。方法择期全麻腹部手术病人 30例 ,分为靶控组和对照组各 15例。靶控组 :TCI泵采用Szenohradszkay模型罗库溴铵药代学参数 ,设定罗库溴铵靶浓度为 3μg/mL ,术中保持T1<10 % ;对照组 :静脉快速 (5s内 )注入 0 .6mg/kg罗库溴铵为插管剂量 ,术中当T1恢复至 2 5 %时间断追加罗库溴铵 0 .15mg/kg。结果起效时间和期间用药量两组均有显著差异 (P <0 .0 1) ,而总用药量、T175 %、恢复指数、TOF70 %均无显著性差异 (P >0 .0 5 )。两组取得的插管条件和T1最大抑制程度相似。结论在中小手术中罗库溴铵TCI法取得了与单次静注法相似的肌松效应 ,并且TCI法获得的肌松效应较间断单次法更稳定更多还原

【Abstract】 Objective To compare neuromuscular blockade of rocuronium of target controlled infusion based on Szenhradszky pharmacokinetic parameter set with intermittent bolus injection. Methods Thirty patients scheduled for abdominal surgery undergoing general anesthesia were divided into two groups. After loss of consciousness, a target blood concentration of 3 μg/mL rocuronium was administered with a TCI syringe driver based on Szenohradszkay pharmacokinetic parameter set and maintained T 1<10% throughout surgery in TCI group (n=15). Bolus dose of 0.6 mg/kg rocuronium was injected intravenously for trachea intubation. 0.15 mg/kg rocuronium was given whenever T 1 restore to 25% in control group (n=15). Results Onset time of control group was significantly faster than that of TCI group (P<0.01).The rocurionium consumption of TCI group was more than control group significantly (P<0.01).There were no significant difference of total dose,recovery time to 75% of T 1,recovery index and recovery time to T 4/T 10.7 between two groups (P>0.05). Equal intubation condition and maximum neuromuscular block of T 1 were obtain in two groups. Conclusion Target control infusion of rocuronium can obtained equal neuromuscular blockade comparing with intermittent bolus injection during short surgery, and muscle relaxation is more stably maintained.更多还原