【摘要】 目的 研究血管紧张素原(AGT)基因第2号外显子T174M和M235T多态与中国汉人脑梗塞发病的关系。方法 采用多重SNaPshot反应,在90例脑梗塞患者和90名健康对照者中,对T174M和M235T多态进行基因分型。结果 T174M多态基因型在脑梗塞组和对照组之间有差异,但未达到统计学意义(P=0.071);T、C等位基因频率与对照组相比有显著性差异(P=0.045)。M235T多态基因型在脑梗塞组和对照组中无显著性差异(P=0.194);脑梗塞组的C等位基因频率高于对照组,但未达到统计学意义(P=O.057)。在男性脑梗塞患者中,M235T多态基因型和等位基因频率与对照组相比均有显著性差异(P=0.030,P=0.011)。结论 AGT基因T174M多态可能与汉族整体人群脑梗塞的发病相关,而M235T多态可能只与男性脑梗塞的发病相关。更多还原

【Abstract】 Objective To evaluate the relationship between T174M and M235T polymorphisms of angiotensinogen (AGT) gene in exon 2 and brain infarction (BI) in Chinese Han population. Methods ABI PRISM SNaPshot multiplex kit was used to genotyping T174M and M235T polymorphisms in 90 patients with BI and 90 healthy controls. Results The genotype distribution of T174M polymorphism was different between BI group and controls, but no statistical difference was found( P = 0. 071 ) . Frequencies of T and C alleles were obviously different between these two groups (P =0. 045) . The genotype distribution of M235T polymorphism had no difference between BI group and controls (P=0.194). The patients’ C allele frequency was higher than the controls , but no statistical difference was found (P =0.057) . However, the genotype distribution and allele frequencies of M235T polymorphism were significantly different between male BI group and male controls ( P = 0. 030 ,P =0. 011 ) . Conclusion T174M polymorphism of AGT gene might be associated with the occurrence of BI in the whole Chinese Han population. M235T polymorphism of AGT gene might be associated with BI in men but not in women.更多还原