【摘要】 目的　探讨孕妇应用硫酸镁对低出生体重儿 (L BW)血清钙、镁水平及 L BW生后重要生命的影响 ,评价产前应用硫酸镁对 L BW的安全性及可行性。方法　将产前应用硫酸镁的孕妇为 A组 (5 5例 ) ,未用硫酸镁者为 B组 (5 8例 ) ,采用日立 710 7型全自动生化分析仪分别测定两组新生儿脐血、生后 72小时内新生儿血清钙、镁浓度、母亲补镁 2 4小时内血钙、镁浓度。用 DASH30 0 0监护仪监护 L BW生后呼吸 (RR)、心率 (HR)、血压(Bp)、血氧饱和度 (Sa O2 )等多项生命指标。结果　脐血清镁浓度 A组 (1.2 0± 0 .32 ) mmol/ L ,B组 (0 .98±0 .32 ) m mol/ L,两组比较 ,P<0 .0 1。脐血清钙的浓度 A组 (1.80± 0 .2 3) mmol/ L,B组 (2 .16± 0 .12 ) mm ol/L,两组比较 P>0 .0 5。L BW生后血清镁浓度 A组 (1.2 0± 0 .2 7) mm ol/ L,B组 (1.0 1± 0 .2 1) mmol/ L,两组比较 P<0 .0 1。两组 L BW在收缩压 (SBP)、舒张压 (DBP)、平均动脉压 (MAP)、HR、RR、Sa O2 等各项指标比较 ,P>0 .0 5。结论　孕妇产前应用硫酸镁 15～ 2 0 g/ d,能提高母 -胎 -新生儿的血清镁的水平 ,对血钙水平无影响 ,未发生镁中毒反应及低钙血症 ,临床应用安全。对 L BW生后 SBP、 DBP、 MAP、 HR、 RR、 Sa O2 均有不同程度的影响 ,但未造成新生儿更多还原

【Abstract】 Objective To study the effect of prenatal magnesium sulfate exposure on infant of low birth weight(LBW) and the signs of life and to evaluate the safety and the possibility of the treatment.Methods 113 cases pregnancy were divided into 2 groups,55 cases in study group had been treated with magnesium sulfate before labour.58 cases in control group had not.Serum Mg 2+ and Ca 2+ levels were measured immediately and within 72 hours after birth.Also measured the pregnant woman’s serum Ca 2+ and Mg 2+ within the 24 hours after giving the medicine.Monitoring the respiratory rate (RR),heart rate (HR),blood pressure (Bp) and SaO 2 of the LBW.Results The umbilical cord serum concentration of Mg 2+ was ( 1.20±0.32)mmol/L (group A) and (0.98±0.23)mmol/L (group B) (P<0.01).The umbilical cord serum concentration of Ca 2+ was( 1.80±0.23)mmol/L (group A) and (1.01±0.21)mmol/L(group B) (P>0.05).The serum Mg 2+ level of LBW was (1.20±0.27)mmol/L(group A) and (1.01±0.21)mmol/L(group B) (P<0.01).The serum a 2+ level was (1.86±0.35)mmol/L(group A) and (1.81±0.25)mmol/L (group B) (P>0.05).No significant difference was showed in both groups about LBW’s SBP,DBP,MAP,HR,RR and SaO 2,(P>0.05).Conclusions Using magnesium sulfate on pregnancy (dose: 15~20g/d) can elevate the serum level Mg 2+ on both mother and infant but no effect on serum Ca 2+.It can effect on the SBP,DBP,MAP,HR,RR and SaO 2 differently but can not cause low blood pressure,low SaO 2 and infant respiratory distress.It is the safety treatment in the clinical.更多还原