【摘要】 目的　探讨肝素酶 (HPA) m RNA在胃癌组织中的表达及其与胃癌临床、病理特征的关系。方法　以原位杂交技术检测 36例胃癌组织 HPA- m RNA的表达。结果　 HPA- m RNA在胃癌组织中的阳性表达率为72 .2 % ,HPA- m RNA表达与胃癌的浸润程度、TNM分期及分化程度有关 (P<0 .0 5 )。结论　 HPA在胃癌发展过程中起重要作用 ,检测 HPA- m RNA表达有望成为判断进展期胃癌预后的标志更多还原

【Abstract】 Objective To investigate the expression of heparanase(HPA)-mRNA and its relation with the clinicopathological features in gastric carcinoma(GC).Methods 36 cases of GC were examined by in situ hybridization technology.Results The positive expression of HPA-mRNA was observed in 26 cases (72.2%).There was significant correlation between the positive expression of HPA-mRNA and depth of invasion,TNM stage,differentiation(P<0.05).Conclusion HPA-mRNA expression may be an important role for the progression of GC.So it perhaps may be used as a marker for prognosis of GC.更多还原