【摘要】 目的:测定正常妊娠期及先兆早产妇女外周血促肾上腺皮质激素释放激素(CRH)、白细胞介素-6(IL-6)水平,探讨妊娠期外周血CRH、IL-6水平的变化及临床意义。方法:测定26例孕妇在妊娠16～20、28～32、37～38周时的血浆CRH、IL-6水平,及31例孕28～35周的先兆早产妇女的血浆CRH、IL-6水平。CRH、IL-6的测定分别用放射免疫法、酶联免疫法。所有孕妇均为健康的单胎初产妇。结果:①妊娠37～38周CRH、IL-6水平均显著高于其余孕周(P<0.01,P<0.05)。妊娠28～32周与16～20周相比CRH水平差异有统计学意义(P<0.05),IL-6水平有升高的趋势,但尚未达统计学水平(P>0.05)。随孕周的增加,IL-6与CRH水平同步升高,二者呈正相关(r=0.86P<0.05);②31例先兆早产的孕妇,其中发生早产的20例孕妇血CRH、IL-6水平显著高于同孕周的正常妊娠组及未发生早产的先兆早产妇女(P<0.05),未发生早产的11例先兆早产妇女与正常妊娠组相比CRH、IL-6虽均有升高的趋势,但差异无统计学意义(P>0.05)。结论:CRH、IL-6可能与分娩发作有关。妊娠期血CRH、IL-6水平异常升高可能是早产发生的高危标志。更多还原

【Abstract】 Objective: To investigate the levels in the maternal plasma corticotropin-releasing hormone (CRH) and interleukin-6 (IL-6) and their relationship to the pregnancy, by determining CRH and IL-6 levels in healthy pregnant women and women with threatened preterm labor. Methods: Maternal blood was taken from 26 healthy pregnant women during 16～20 weeks, 28～32 weeks and 37～38 weeks, and 31 women with threatened preterm. Plasma CRH and IL-6 concentrations were determined by radioimmunoassay and enzyme-linked immunosorbent assay respectively. Results: ① Maternal plasma CRH and IL-6 levels during 37～38 weeks gestation were higher than those during the former weeks gestation (P<0.01, P<0.05). Compared with those in between 16 and 20 weeks gestation, maternal plasma CRH levels between 28～32 weeks gestation were elevated (P<0.05), but there was no statistical significance between IL-6 concentrations (P>0.05), even though IL-6 had a tendency to rise between 28～32 weeks gestation. IL-6 levels were positively correlated with CRH levels (r=0.86, P<0.05); ② Among 31 women with threatened preterm labor , there were 20 women delivered preterm whose plasma CRH and IL-6 concentrations were higher than the rest who delivered at term (P<0.05) or the normal controls(P<0.05). In the women with threatened preterm labor but delivered at term, plasma CRH and IL-6 levels were not different from normal controls(P>0.05). Conclusion: The results suggest that CRH and IL-6 may play a role in the physiology of term parturition. CRH and IL-6 may be the markers of antepartum risk for preterm delivery.更多还原