【摘要】 核酸二级数据库是生物信息学研究的重要领域 ,对生命科学的研究和发展起重要作用 .目前 ,国际核酸序列公共数据库中存在大量的细菌 16SrDNA序列 ,本文利用这些已知细菌的 16SrDNA序列 ,设计了细菌种特异性的寡核苷酸探针 ,将其结果存入二级数据库 ,以计算机网络为载体 ,开发了界面友好的通过WWW浏览器实现对数据库查询的系统 ,其查询结果形象直观 ,为设计细菌的种特异性寡核苷酸探针提供了参考和帮助 ,从而可加速对细菌分类及鉴定的进程 .更多还原

【Abstract】 The secondary database that play an important role in the research and development of biology is a vital research subject in the field of bioinformatics.At present,there are enormous 16S rDNA sequences of bacteria available in the Genbank.In this paper the species-specific oligonucleotide probes for various bacteria according to 16S rDNA have been designed and stored into a database.And an user-friendly search system based on computer network has been constructed.This secondary database could be helpful for users to design oligonucleotide probes to classify and identify the bacteria more rapidly.更多还原