【摘要】 目的　比较噻奈普汀 (商品名达体朗 )与帕罗西汀治疗抑郁症的有效性和安全性。方法　将 6 8例符合CCMD 2 R诊断标准的抑郁症患者 ,随机分为噻奈普汀组与帕罗西汀组 ,治疗 6周。用汉密顿抑郁量表(HAMD)评定疗效 ,用副反应量表 (TESS)评定副反应。结果　治疗 6周后噻奈普汀组和帕罗西汀组的有效率分别为 77%和 82 % ,二者比较差异无显著性。治疗 6周后两组HAMD总分及焦虑躯体化因子分 ,治疗前后比较差异均有显著性 ,两组间比较差异无显著意义。噻奈普汀组主要不良反应是嗜睡、口干等 ,与帕罗西汀组相比 ,差异无显著性。结论　噻奈普汀是安全、有效的抗抑郁药物更多还原

【Abstract】 Objective To compare efficacy and safety of tianeptine and paroxetine in the treatment of major depressive disorder.Methods Sixty-eight patients who met the criteria of CCMD-2-R for depressive disorder were randomly divided into two subgroups receiving treatment of tianeptine and paroxetine respectively for six weeks . The efficacy was assessed by Hamilton Depression rating scale (HAMD), and the safety was assessed by Treatment Emergent Symptom Scale ( TESS).Results The efficacy rates of the tianeptine group and the paroxetine group were 77% and 82%,respectively. There was no significant differance between two groups on efficacy rate. The scores of HAMD and the sub-scores of HAMD in anxiety somatization in two groups had significant differences between before and after treatment, no significant difference existed between two groups. The main adverse reactions of tianeptine group were drowsiness,dry mouth.Conclusion Tianeptine is an effective and well tolerated antidepressant.更多还原