【摘要】 目的 :探讨乙肝病毒 (HBV)感染对非霍奇金淋巴瘤 (non Hodgkin’slymphoma ,NHL)化疗后肝功能的影响。方法 :对 95例中高度NHL患者 ,采用ELISA法和直接斑点杂交法检测血清中的HBV标志物及DNA ,常规方法检测化疗前后肝功能。结果 :HBsAg阳性率 3 3 68% ( 3 2 /95 ) ,化疗后 62 5 0 % ( 2 0 /3 2 )HBsAg( +)和 14 2 9% ( 9/63 )HBsAg( -)肝功能损害 ,两组差异有统计学意义 ,P <0 0 1;肝功损害达中重度和持续时间达 2～ 4个月的患者 ,HBsAg( +)组都占 5 5 % ( 11/2 0 ) ,HBsAg( -)组都占 11 1% ( 1/9) ,损害程度和持续时间两组差异都有统计学意义 ,前者较后者重 ,持续时间长 ;14例HBsAg( +)发生肝功能损害时病毒复制再度活跃。结论 :NHL患者化疗后HBsAg( +)较HBsAg( -)易发生肝功损害 ,而且前者较后者重、持续时间长 ;化疗后病毒复制再度活跃是发生肝功损害的重要原因。更多还原

【Abstract】 OBJECTIVE:To observe the effect of hepatis B virus infection on liver function in non-Hodgkin’s lymphoma (NHL) patients treated with chemotherapy.METHODS:Serum HBV markers and HBV-DNA were determined by ELISA and direct spot hybridization in 95 cases of NHL. The liver function of all cases was normal before chemotherapy.After chemotherapy, the patients’ liver function were observed again. RESULTS:Among 95 cases of NHL, 32 cases were positive HBsAg.After two cycles of chemotherapy,abnormal liver function rate was 62.50%(20/32) in positive HBsAg cases and 14.29%(9/63) in negtive HBsAg cases,P<0.01. The middle-high degree damage of liver function was 55%(11/20)in HBsAg(+) group and 11.1%(1/9)in HBsAg(-) group respectively.Their duration were between 2 and 4 months. The degree and duration of liver function damage between two groups were significantly different. The liver function damage could be attributed to reactivation of HBV replication in 14 cases of HBsAg (+) . CONCLUSIONS:NHL patients with HBsAg(+) are most likely subjected to liver function damage. Reactivation of HBV replication is an important factor of liver function damage.更多还原