【摘要】 目的 对106对已确定为无症状携带乙肝表面抗原(HBsAg)阳性母亲的血清及其新生儿脐血中乙肝五项标志物进行检测研究,旨在通过观察分析母婴宫内HBV感染的相关性,探讨胎盘在其感染过程中的屏障作用。方法应用酶联免疫吸附法(ELISA)检测乙肝五项标志物。结果母亲组:HBsAg(+)106例(100％);HBsAb(-)106例(100％);HBsAg(+)／HBeAg(+)／HBcAb(+)39例(36.79％);HBsAg(+)／HBeAb(+)／HBcAb(+)66例(66.26％);HBsAg(+)／HBcAb(+)1例(0.94％)。脐血组:106例脐血检测标本为HBsAg(一),其它的组合模式完全同母亲组。结论母亲HBsAg(+)的新生儿脐血中含有HBV感染、复制的标志物(HBeAg、HBeAb、HBcAb)存在,脐血中乙肝标志物高效率的表达,表明母血中HBV能够通过胎盘组织侵入胎儿血循环,胎盘屏障不能阻止胎儿HBV官内感染。更多还原

【Abstract】 Objective To evaluate the role of placenta between 106 pregnant women plasma HBsAg positive and newborn babies with hepatitis B. To explore the effection of placenta by measuring fire immunological marker of HBV in newborn babies’ s umbilical cord blood. Methods ELISA method was used for detection of five HBV immunological marker. Results in pregnant women group: 106 cases( 100%) showed HBsAg( + ) positive; 106 Cases(100%) showed HBsAb( - );39 cases(36.79%) showed HBsAg ( + ),HBeAg( + ),HBcAg( + );66 cases (66.26%) showed HBsAg( + ), HBeAb( + ),HBcAb( + );only one case(0.94%) HBsAg( + ),HBcAb( + ). in newborn babies group: 106 cases of newborn babies was detectecld to show HBsAg( - ) 、BsAb( - ) in their umbilical cord blood, the other model of HBV immunological showed the same result as that of pregnant women group. Conclusion placenta barrier can’t per vent HBV infection in newborn babies through umbilical cord.更多还原