节点文献
根除幽门螺杆菌对消化性溃疡患者胃泌素表达水平的影响
The Effect of Helicobacter Pylori Eradication on the Expression of Gastrin in patients with Active Peptic Ulcer
【摘要】 目的 通过观察根除幽门螺旋杆菌对消化性溃疡患者胃泌素基因表达水平及血清胃泌素分泌影响 ,来探讨Hp可能的致病机理。方法 对Hp阳性的 6 1例消化性溃疡患者 ,给予质子泵抑制剂 (洛赛克 2 0mg/d)、甲硝唑(0 8g/d ,分 2次服 )和阿莫西林 (1 0 g/d ,分 2次服 )联合抗Hp治疗 2周 ,治疗前及治疗后分别检测胃泌素及胃泌素基因。结果 在GU患者中 ,Hp根除组胃泌素基因表达水平从治疗前的 (0 36± 0 11) μg/gpro变为治疗后的(0 2 7± 0 0 9) μg/ gpro (P <0 0 1)。在DU患者中 ,Hp根除组胃泌素基因表达水平和胃泌素水平分别从治疗前的(0 4 2± 0 16 ) μg/gpro和 (38 2± 11 3) pmol/L变为治疗后的 (0 2 7± 0 17) μg/ gpro和 (30 3± 10 6 )pmol/L ,治疗前后比较差别均有非常显著性意义 (P均 <0 0 1)。结论 Hp感染导致胃泌素基因表达水平及胃泌素分泌增加与十二指肠溃疡的发生关系更为密切 ,根除Hp可使胃泌素基因的表达水平明显下降。胃溃疡患者中 ,胃泌素分泌的调节除与胃泌素基因表达相关外 ,还受胃酸的负反馈等其他机制的影响。
【Abstract】 Objective To observe the effect of Helicobacter pylori eradication on the expression of gastrin with active gastric ulcer and duodenal ulcer patients.Methods 61 H.pylori positive patients with peptic ulcer were given anti-H.Pylori therapy,the expression of gastrin gene were detected by RT-PCR,and the plasma gastrin concentration was measured by RIA.Results After therapy,the expression levels of gastrin gene declined from (0.42±0.16)μg/gprot to (0.27±0.17)μg/gprot in Hp eradicated group in the duodenal ulcer patients(P<0.01),and from (0.36±0.11) μg/gprot to (0.27±0.09)μg/gprot in Hp eradicated group in the gastric ulcer patients,this was significantly declined(P<0.01).The plasma gastrin concentrations declined from (38.2±11.3)pmol/L to (30.3±10.6)pmol/L in the duodenal ulcer patients(P<0.01).Conclusion H.pylori may enhance gastrin gene expression and gastrin release,it is apparently decreased after Hp eradication,especially in those duodenal ulcer cases.In gastric ulcer,there maybe other factors are related with gastrin release except for gastric gene.
- 【文献出处】 中国全科医学 ,Chinese General Practice , 编辑部邮箱 ,2004年19期
- 【分类号】R573.1
- 【被引频次】66
- 【下载频次】201