【摘要】 目的 :探讨霉酚酸酯 (MMF)联合低剂量环孢素A(CsA )、百令胶囊 (Q80 )治疗慢性移植肾肾病 (CAN)的临床疗效。方法 :35例同种异体肾移植受者经临床及移植肾活检诊断为CAN ,在原使用硫唑嘌呤 (Aza)、CsA、泼尼松 (Pred)基础上随机分为A、B两组 ,A组 :用MMF(1.0～ 1.5 )g/d +CsA[血CsA谷值 (10 0～ 15 0 )ng/ml]+Pred(10mg/d) +Q80 (3.0～ 6 .0 )g/d ;B组 :采用CsA[血CsA谷值 (15 0～ 2 0 0 )ng/ml]+Aza(5 0mg/d) +Pred(10mg/d)。随访 1年 ,观察两组移植肾功能、肾小球滤过率、尿蛋白、血压的变化。结果 :随访 1年 ,观察指标稳定或改善者A组 85 .0 % (17/ 2 0 ) ,B组 4 0 .0 % (6 / 15 ) ,两组间差别有显著性 (P <0 .0 5 )。结论 :MMF联合低剂量CsA、百令胶囊治疗慢性移植肾肾病有较好的疗效更多还原

【Abstract】 Objective:To investigate the curative effects of mycophenolate mofetil (MMF) united low level cyclosporin (CsA) and cultivated cordyecos sinensis (Q 80) method on the treatment of chronic allograft nephropathy (CAN). Method:35 cases which confirmed clinical and biopsy diagnosis of CAN after homograft kidney transplant randomly divided into Group A: switched from azathioprine to MMF (20 cases), Group B: continually treatment of Aza (15 cases).Group A: MMF (1.0～1.5)g/d + CsA [blood CsA (100～150)ng/ml] + prednisone (10mg/d) + Q 80 (3.0～6.0)g/d; Group B: CsA [blood CsA (150～200)ng/ml] + Azathioprine (50mg/d) + Prednisone (10mg/d). The transplanted kidney function, glomerular filtration rate (GFR), protein urine, blood pressure level was tracked and observed in all cases in one year. Results: After one year continued therapy, in the group A, the GFR and protein urine was stable or apparently improved 85.0% (17/20), Group B was 40.0%(6/15). There was significant difference between the two groups. (P<0.05). Conclusion: MMF united low level CsA and Q80 method have a better curative effect of the treatment of chronic allograft nephropathy (CAN).更多还原