【摘要】 DNA拓扑异构酶Ⅱ(TopoisomeraseⅡ,TopoⅡ)是一种真棱生物生存所必需的泛酶,在几乎所有DNA代谢过程中发挥重要作用。因为TopoⅡ具有重要的生理功能,它已成为抗癌药物的重要作用靶点。近年来,对TopoⅡ催化机制和药物作用方式的研究取得了很大进展,这些发现有助于进一步了解TopoⅡ的生理功能,进而研究出更有效的治疗方案和新的抗癌药。本文介绍了以TopoⅡ为靶点的抗癌药物的作用机制及其发展现状。更多还原

【Abstract】 DNA topoisomerase Ⅱ(Topo Ⅱ)is a ubiquitous enzyme that is essential for survival of the eukaryotic organisms , playing an important role in most processes of the DNA mechanisms. In addition to its critical cellular functions, Topo Ⅱ is an important target for a number of the most active and widely prescribed anticancer drugs. Over the past several years , great progress has been made in the catalytic mechanisms of Topo Ⅱand the mechanism of action of drugs targeting this enzyme. These advances have provided novel insight into the physiological functions of Topo Ⅱ and have led to the development of more efficacious chemotherapeutic regimens and new anticancer drugs. The anti-cancer mechanism of Topo Ⅱ inhibitors and the status of development are introduced in this review.更多还原