【摘要】 目的选择大鼠各个肠段进行肠吸收试验,考察氧化苦参碱在大鼠小肠十二指肠、空肠、回肠及结肠部位的吸收情况,确定是否存在药物特异性吸收部位,以此来证明氧化苦参碱制备成缓释制剂的可能性。方法采用大鼠离体小肠外翻肠囊法试验,用HPLC法检查肠液中药物浓度。结果苦参素在2 h内空肠和回肠中的累积吸收量最大,在十二指肠和结肠的吸收量次之,依次为338.5、318.8、228、201.5μg·h-1。结论氧化苦参碱在小肠各肠段均无特异吸收,适合制成缓释制剂。更多还原

【Abstract】 Objectives To study the absorption rate at different segment of rats and to determine if specific absorption site existed and the feasibility of the extended release preparation. Methods: Everted gut sac was used to compare the absorption of oxymatrine in jejunum,ileum,duodenum and colon. The concentration of oxymatrine in the intestinal medium was determined by HPLC method. Results: The highest absorption extent of oxymatrine was observed in the jejunum and ileum and the lower absorption rate was observed in duodenum and colon,with 677,637,456 and 403μg·h-1,respectively. Conclusions:No significant difference in absorption rage between each segment of the rats’ intestine. It was possible to formulation oxymatrine to extented release dosage forms according to the absorption study.更多还原