【摘要】 目的 :研究Fas和Fas配体 (FasL)在胃癌组织中的表达规律及可能的意义。方法 :采用免疫组化方法 ,检测 5 8例胃癌组织和 2 6例非胃癌组织 (对照 )中Fas和FasL蛋白的表达。结果 :胃癌组织中胃癌细胞和对照组织中胃上皮细胞Fas阳性率分别为 19.0 %和 6 1.5 % ;胃癌组阳性率明显低于对照组(χ2 =14 .918;P =0 .0 0 0 )。胃癌组织中胃癌细胞和对照组织中胃上皮细胞FasL阳性率分别为 6 3.8%和 5 3.8% ,两组差异无统计学意义。结论 :胃癌细胞Fas FasL系统平衡失调 ,可能与胃上皮细胞癌变及免疫逃逸有关更多还原

【Abstract】 Objective:Study on the expression of Fas and Fas ligand (FasL) in gastric cancer and its possible significance.Methods:Fifty-eight paraffin-embedded gastric cancer tissues and twenty-six non-cancer tissues were tested for the expression of Fas and FasL protein by immunohistochemistry.Results:The positive rate of Fas in cancer cells of gastric cancer tissues was significantly lower than that in gastric epithelial cells of the control tissues(19.0% and 61.5%,respectively;χ~2=14.918;P=0.000).The positive rate of FasL showed no significant difference between cancer cells of gastric cancer tissues and gastric epithelial cells of the control tissues(63.8% and 53.8%,respectively).Conclusion:The Fas-FasL system is unbalanced.It may be related to the carcinogenesis of gastric epithelial cells and might be responsible for the immune excape of these cells.更多还原