【摘要】 报道了由对羟基苯甲酸甲酯、肼、二硫化碳、1,　2-二溴乙烷为原料合成一种新型硫杂环化合物-2-(4’-羟基苯甲酰亚肼基)-1,　3-二硫杂环戊烷,对其结构进行了表征,并初步测试了其生物活性。生物活性试验表明该化合物对大肠杆菌、金葡菌、肺炎克雷伯氏菌、绿脓杆菌和草绿色链球菌均有一定活性,对草绿色链球菌(1123号)的抗菌效果与头孢噻肟(CET)、磺胺甲基异恶唑相当(SMZ)。更多还原

【Abstract】 Anewheterocyclicsulfurcompound, 2-(4′-hydroxybenzoy1-hydrazono)-1,3-dithiolane,was synthesized using methyl 4-hydroxybenzoate, hydrazine, carbon disulfide, and 1,2-dibromoethane as reagants. The structure of the product was confirmed and preliminary biological activity testing was conducted. The compound has activity against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Streptococcus, with bactericidal activity against Streptococcus (No. 1123)equivalent to cetotaxime (CET)and sulfamethoxazole (SMZ).更多还原